E is a potent
antioxidant with proven anti-cancer activity that also has proven
protective effects against cardiovascular disease. In its natural
food state, Vitamin
E is actually a family
of seven different tocopherols, but the form used for most
supplements and medical studies is the alpha- tocopherol
E was originally
isolated from wheat germ oil. Its fat-soluble properties allow
Vitamin E to function as a potent antioxidant in both
the fat-soluble and the water-soluble parts of the cell
E helps maintain cell
wall integrity and preserve energy metabolism of the cell by
inhibiting lipid peroxidation of cell membranes.
Vitamin E is also an immune-enhancer and protects
against pollution-derived lung
The anticancer activity of
Vitamin E is thought to be via its antioxidant action and
immune enhancement properties. Vitamin E works synergistically with other potent cellular
antioxidants including Selenium, Vitamin C, zinc and others. For
E enhances the cancer
preventive effect of Selenium on chemical-induced breast cancer in rats,
acts with zinc as a stabilizer of cell membranes, requires Selenium for
adequate absorption from the gastrointestinal tract, is destroyed more
readily by free radicals in the presence of copper or iron unless adequate
Vitamin C is present, and is required to maintain normal levels of Vitamin
A in the liver and plasma.
E has been shown to be
one of the strongest protectors against the environmental pollutants,
ozone and nitric oxide. Nitrites are major sources of free radical
damage to cells. Nitrites form with amines in the gut to form
carcinogenic compounds. Nitrites, like many chemicals, are not
carcinogenic until they are converted to an active form in the body.
In some cases Vitamin
E can prevent the
conversion of inactive forms of such cancer causing substances to
E also prevents the
action of tumor promoting and tumor initiating agents which are
present in the environment and diet.
E influences the
effectiveness of many drugs currently used in cancer treatment. In
vitro studies show, for example, that Vitamin E acetate in combination with vincristine,
5-fluorouracil,adriamycin, or chlorozotocin produces a synergistic
effect, whereas Vitamin
E in combination with
triazeno-imidazole-4-carboxamie (DTIC), mutamycin or cis- diamine)
dichloro-platinum II (cis-platinum II) produces an additive effect in
inhibiting growth of neuroblastoma cells.
In glioma cell cultures,
Vitamin E acetate in combination with vincristine or CCNU
produces a synergistic effect, whereas Vitamin E in combination with bleomycin, 5-fluorouracil,
adriamycin, DTIC, mutamycin and cis-platinum produces an additive effect on
the inhibition of growth.
These studies suggest that the
effectiveness of the interaction of Vitamin E with cancer chemotherapeutic drugs depends upon
tumor form and type of drug. Vitamin E also enhances the effect of some naturally
occurring substances such as prostaglandins and sodium butyrate on
neuroblastoma cells in vitro. The relevance of the above results in humans
is not known at this time.
E appears to protect
against radiation damage and to also protect against
radiation-induced cancers in vitro. Vitamin E protects cells from the toxicity of certain
heavy metals, including mercury-induced brain damage.
Vitamin E also protects against lung damage generated
by cigarette smoke.
E appears to protect
against various cancers through several actions:
Vitamin E kills tumor cells directly, enhances the
effect of tumor therapeutic agents (drug, radiation and heat),
reduces the toxic effect of tumor cells, and enhances normal immune
E's ability to reduce free
radicals may slow aging and reduce risk of cancer
>> NOTE: Each serving of Ellagic Insurance Formula
contains 400IU of Vitamin