According to the latest published
information Graviola has
been researched in laboratory tests since the 1970s, where it's been shown
- Effectively target and kill
malignant cells in 12 different types of cancer, including Colon, Breast,
Prostrate, Lung and Pancreatic Cancer.
- Be 10,000 times stronger in killing
colon cancer cells than Adriamycin (a commonly used chemotherapeutic
- Selectively hunt down and kill
cancer cells without harming healthy cells, unlike
Graviola is a small, upright evergreen tree growing 5 to 6
meters in height with large dark green and glossy leaves. It is indigenous to
most of the warmest tropical areas in South and North America including the
Amazon. It produces a large heart-shaped edible fruit that is 6-9", yellow
green in color, with white flesh. The fruit is sold in local markets in the
tropics where it is called Guanabana or Brazilian Cherimoya and is excellent
for making drinks and sherbets and, though slightly sour-acid, can be eaten
In an 1976 plant screening program by the
National Cancer Institute, the leaves and stem of Graviola showed
active cytotoxicity against cancer cells and researchers have been following up
on this research ever since.
Much of the research on
Graviola focuses on a novel set of phytochemicals called
The potent antitumor, pesticidal and/or insect
antifeedant properties of these annonaceous acetogenins have been reported and
patented. Graviola produces these natural compounds in leaf, bark and twig
tissues, and they have be documented to possess both highly anti-tumor and
- Mode of action studies in three separate
laboratories have recently determined that acetogenins are superb
inhibitors of Complex I in mitochondrial electron transport systems from
several organisms including tumors.
- Research on various Annona species of
plants has yielded many extremely potent acetogenins. Many of them have
cytotoxicity with ED50 values as low as 10-9 ug/ml.
- Active compounds from
Graviola and other Annona plants have been submitted to the
NIH anti-AIDS screen by Purdue University and their work is continuing with
a number of other active plant species in the Annona plant family. Thus
far, Purdue and/or it's staff have filed at least 9 U.S. and/or
international patents on their work around the antitumorous and
insecticidal properties and uses of these acetogenins.
- Three separate research groups have
isolated novel compounds in the seeds and leaves of
Graviola which have demonstrated significant
anti-tumorous, anticancerous and selective toxicity against various
types of cancer cells, publishing 8 clinical studies on their
- One study demonstrated that an acetogenin
in Graviola was
selectively cytotoxic to colon adenocarcinoma cells in which it was
10,000 times the potency of adriamycin (a chemotherapy
- Cancer research is ongoing on
Graviola, and four new studies have been published in 1998 which
further narrow down the specific phytochemicals which are demonstrating the
strongest anticancerous and antiviral properties.
Annonaceous acetogenins are only found in the Annonaceae family. In general,
various annonaceous acetogenins have been documented with antitumor,
antiparasitic, pesticidal, antiprotozoal, antifeedant, anthelmintic, and
antimicrobial activities. There has been much interest in the chemicals which
have demonstrated potent antitumor properties and several research groups are
trying to synthesize these chemicals for new chemotherapeutic drugs.
In a review of these natural chemicals in The Journal of Natural Products in
1999 they noted: "The Annonaceous acetogenins are promising new antitumor and
pesticidal agents that are found only in the plant family Annonaceae.
Chemically, they are derivatives of long-chain fatty acids. Biologically, they
exhibit their potent bioactivities through depletion of ATP levels via
inhibiting complex I of mitochondria and inhibiting the NADH oxidase of plasma
membranes of tumor cells. Thus, they thwart ATP-driven resistance
Another review in the Skaggs Scientific Report
1997-1998 states, "Annonaceous
acetogenins, particularly those with adjacent bis-tetrahydrofuran (THF)
rings, have remarkable cytotoxic, antitumor, antimalarial,
immunosuppressive, pesticidal, and antifeedant activities. Many of these
fatty acid derivatives have similar carbon skeletons; their striking
diversity originates mainly from the relative and absolute configuration
of their various stereogenic oxygen functions."
>> NOTE: Each serving of Ellagic Insurance Formula
contains 600mg of Graviola.