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The War Against Cancer-
Can Beta Glucan Serve a Role?

An article by A. J. Lanigan
CEO, Transfer Point

For many decades, immune therapy has been investigated, utilized, and found to have frequent success in helping the body's immune system fight disease. One of the most feared diseases, cancer, continues to take its toll. Until a cure is found, we may have some answers to slow the progression or help the recovery of cancer patients. One area of immune enhancement concentrates on complex carbohydrates, specifically beta glucan.

In the United States, and in various other parts of the world, the Beta 1, 3-D polyglucose (a complex carbohydrate) molecules have come under intense scrutiny. The Japanese have extracted a pharmaceutical material from a fungal form and called it Krestin (PSK). This is a protein bound carbohydrate molecule that has exhibited antitumor effects in many test tube, animal, and human studies. It exhibits many of the classical characteristics of its U.S. relative, Beta Glucan (BG) from baker’s yeast. Beta Glucan has almost 40 years of peer reviewed research attesting to its safety and efficacy. Baker’s yeast (also a fungal form) carries a GRAS (Generally Regarded As Safe) rating from the FDA, having no known toxicity. Although the mushroom fungal material cannot make that claim, animal experiments have shown little toxicity at 20,000 mg/kg of body weight. That would be over 1600 grams (3.5 lbs.) for a 150 lb. human. (drink plenty of water with that dose).

In further comparison, the PSK contains about 75% of the glucose linkage backbone versus 95% in BG. The side chains of these polybranched sugar molecules vary as well. With PSK, mannose, xylose, galactose, and fucose sugars side branch to the 1,3 linkage central sugar molecule. Many U.S. scientists have determined that these side chain variations and frequencies hold the "key into a lock" mechanism that causes certain immune cells to fight the fight and communicate better to defeat cancer and other diseases. Perfecting processes that purify without destroying these natural molecules are imperative in giving researchers and clinicians the material they need to properly dose and deliver consistent results. We see the 1,3 glucose at around 85% with 3-5% 1,6 glucose side chains in BG.

Although many aspects of exactly how these complex molecules work in the immune system are not clearly understood, four decades of experimentation and use dictate that something is there meriting the use of the material. Scientists and clinicians largely agree that these complex carbohydrates will help return suppressed or enhanced immune responses back to normal levels. In the Killer T cell population (an important antitumor immune cell), activity levels correlate well with the use of these complex carbohydrates. Natural Killer cells and complement show significant effectiveness, according to considerable research by several institutions in the US. Other immune suppressing substances seem to be negated and the intestinal immune system, in particular, appears to be modulated by the oral doses. Finally, it is noted that both the large and the small molecules pass through the intestine and can be traced to the blood using appropriate tracking techniques when taken orally.

We are happy to announce a continuation of human clinical trials using our Beta Glucan along side the conventional medical treatments. We expect to clearly show the efficacy of our material, when appropriate steps are taken to purify the BG, while leaving the active molecules intact. With a standardized material such as ours, researchers and clinicians can always depend upon the correct dosage. This will help to provide the best immune response and positive outcomes for their patients.


Potency Of This Product

This chart reflects the results of a major US university testing on a side-by-side competitive basis, the ability of Transfer Point's Beta 1, 3-D Glucan, manufactured by Transfer Point ( A. J. Lanigan AKA: AJs) to increase the number of immune cells (expressed here in a percentage) that are attacking and destroying non-self targets. All these cells have CR3 (1, 3/1, 6 glucan) receptors.

This is an ongoing study that will help to eliminate any confusion in the market place relative to which compounds and what brands of product perform the best.

Transfer Point offers customers a comprehensive assay detailing both purity and potency. No one in the industry has ever matched their purity and potency, regardless of claims. Many competitors are unwilling to provide you with such information, calling it proprietary. As a consumer, paying for a product based upon specific claims of purity and potency, you are entitled to know what you have bought.

  • Two companies were tested at up to 160 times the dose of Transfer Point stand alone Beta 1, 3-D Glucan. They are shown at or near the negative control (30.6%).

  • Numerous assays have confirmed to date that “loading” or putting 2-3 times the amount of powder into a single dose does next to nothing. If fact, Transfer Point tested up to 64:1 and that level failed in every instance to double the biological effective of the compounds tested.

  • Transfer Point tested for the production of 14 cytokines (immune system messenger molecules), including the inflammatory cytokines. Their compounds showed zero (0) to nearly non-detectable levels. Some immune supplements may actually be deleterious when used too often or if the individual already has issue with disease that does not fair well with excessive inflammation.

  • Transfer Point compounds produce significant levels of IL-2*. This is a key cytokine that results in many positive effects on the overall immune system and its ability to respond, especially to cancer and viruses.

*IL-2 - Interleukin-2 was discovered more than 20 years ago. IL-2 is part of a family of proteins called cytokines. Cytokines act primarily by communicating between the various cells of the body's immune system. IL-2 helps increase production of several different components of the immune system found in the blood, including T lymphocytes and natural killer cells. It also may improve the function of other immune system cells, such as lymphokine-activated killer (LAK) cells and tumor-infiltrating lymphocytes. This helps the body fight cancer.

IL-2, produced and secreted by activated Th1-cells, is the major interleukin responsible for clonal T-cell proliferation. The production of IL-2 occurs primarily by CD4+ T-helper cells. The IL-2 receptor is not expressed on the surface of resting T-cells and is present only transiently on the surface of T-cells, disappearing within 6-10 days of antigen presentation. In contrast to T-helper cells, NK cells constitutively express IL-2 receptors and will secrete TNF-a, IFN-g and GM-CSF in response to IL-2, which in turn activate macrophages. The U.S. Food and Drug Administration approved a synthetic form of IL-2 (Proleukin) for treatment against cancer in 1992.

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